The Aedes aegypti siRNA pathway mediates broad-spectrum defense against human pathogenic viruses and modulates antibacterial and antifungal defenses

The mosquito’s innate immune system defends against a variety of pathogens, and the conserved siRNA pathway plays a central role in the control of viral infections. Here, we show that transgenic overexpression of Dicer2 (Dcr2) or R2d2 resulted in an accumulation of 21-nucleotide viral sequences that...

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Detalles Bibliográficos
Autores principales: Dong, Yuemei, Dong, Shengzhang, Dizaji, Nahid Borhani, Rutkowski, Natalie, Pohlenz, Tyler, Myles, Kevin, Dimopoulos, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182253/
https://www.ncbi.nlm.nih.gov/pubmed/35679279
http://dx.doi.org/10.1371/journal.pbio.3001668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182253/
https://www.ncbi.nlm.nih.gov/pubmed/35679279
http://dx.doi.org/10.1371/journal.pbio.3001668

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