Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan

Inhibiting tyrosyl-DNA phosphodiesterase 1 (TDP1) is a promising strategy for increasing the effectiveness of existing antitumor therapy since it can remove the DNA lesions caused by anticancer drugs, which form covalent complexes with topoisomerase 1 (TOP1). Here, new adamantane–monoterpene conjuga...

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Detalles Bibliográficos
Autores principales: Munkuev, Aldar A., Dyrkheeva, Nadezhda S., Kornienko, Tatyana E., Ilina, Ekaterina S., Ivankin, Dmitry I., Suslov, Evgeniy V., Korchagina, Dina V., Gatilov, Yuriy V., Zakharenko, Alexandra L., Malakhova, Anastasia A., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182348/
https://www.ncbi.nlm.nih.gov/pubmed/35684313
http://dx.doi.org/10.3390/molecules27113374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9182348/
https://www.ncbi.nlm.nih.gov/pubmed/35684313
http://dx.doi.org/10.3390/molecules27113374

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