Transformation of dolutegravir into an ultra-long-acting parenteral prodrug formulation

Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18-carbon chain modified ester prodrug nanocrystal (coined NM2DTG) with the potential to sustain yearly dosing. Here, we sho...

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Detalles Bibliográficos
Autores principales: Deodhar, Suyash, Sillman, Brady, Bade, Aditya N., Avedissian, Sean N., Podany, Anthony T., McMillan, JoEllyn M., Gautam, Nagsen, Hanson, Brandon, Dyavar Shetty, Bhagya L., Szlachetka, Adam, Johnston, Morgan, Thurman, Michellie, Munt, Daniel J., Dash, Alekha K., Markovic, Milica, Dahan, Arik, Alnouti, Yazen, Yazdi, Alborz, Kevadiya, Bhavesh D., Byrareddy, Siddappa N., Cohen, Samuel M., Edagwa, Benson, Gendelman, Howard E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184486/
https://www.ncbi.nlm.nih.gov/pubmed/35680875
http://dx.doi.org/10.1038/s41467-022-30902-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184486/
https://www.ncbi.nlm.nih.gov/pubmed/35680875
http://dx.doi.org/10.1038/s41467-022-30902-7

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