Severe cellular stress drives apoptosis through a dual control mechanism independently of p53

For past two decades, p53 has been claimed as the primary sensor initiating apoptosis. Under severe cellular stress, p53 transcriptional activity activates BH3-only proteins such as Bim, Puma, or Noxa to nullify the inhibitory effects of anti-apoptotic proteins on pro-apoptotic proteins for mitochon...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yen-Chun, Wang, Li-Ting, Hung, Ta I, Hong, Yi-Ren, Chen, Chung-Hwan, Ho, Cheng-Jung, Wang, Chihuei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184497/
https://www.ncbi.nlm.nih.gov/pubmed/35680784
http://dx.doi.org/10.1038/s41420-022-01078-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184497/
https://www.ncbi.nlm.nih.gov/pubmed/35680784
http://dx.doi.org/10.1038/s41420-022-01078-2

Ejemplares similares