Structural Basis for pH-gating of the K(+) channel TWIK1 at the selectivity filter

TWIK1 (K2P1.1, KCNK1) is a widely expressed pH-gated two-pore domain K(+) channel (K2P) that contributes to cardiac rhythm generation and insulin release from pancreatic beta cells. TWIK1 displays unique properties among K2Ps including low basal activity and inhibition by extracellular protons throu...

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Detalles Bibliográficos
Autores principales: Turney, Toby S., Li, Vivian, Brohawn, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184524/
https://www.ncbi.nlm.nih.gov/pubmed/35680900
http://dx.doi.org/10.1038/s41467-022-30853-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184524/
https://www.ncbi.nlm.nih.gov/pubmed/35680900
http://dx.doi.org/10.1038/s41467-022-30853-z

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