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Extracellular release of two peptidases dominates generation of the trypanosome quorum-sensing signal

Trypanosomes causing African sleeping sickness use quorum-sensing (QS) to generate transmission-competent stumpy forms in mammalian hosts. This density-dependent process is signalled by oligopeptides that stimulate the signal transduction pathway leading to stumpy formation. Here, using mass spectro...

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Detalles Bibliográficos
Autores principales: Tettey, Mabel Deladem, Rojas, Federico, Matthews, Keith R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184580/
https://www.ncbi.nlm.nih.gov/pubmed/35680928
http://dx.doi.org/10.1038/s41467-022-31057-1