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Activation of CD44 signaling in leader cells induced by tumor-associated macrophages drives collective detachment in luminal breast carcinomas

Collective detachment of cancer cells at the invading front could generate efficient metastatic spread. However, how cancer cell clusters shed from the leading front remains unknown. We previously reported that the dynamic expression of CD44 in breast cancers (BrCas) at collectively invading edges w...

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Detalles Bibliográficos
Autores principales: Gao, Feng, Zhang, Guoliang, Liu, Yiwen, He, Yiqing, Sheng, Yumeng, Sun, Xiaodan, Du, Yan, Yang, Cuixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184589/
https://www.ncbi.nlm.nih.gov/pubmed/35680853
http://dx.doi.org/10.1038/s41419-022-04986-4