Evolutionary action of mutations reveals antimicrobial resistance genes in Escherichia coli

Since antibiotic development lags, we search for potential drug targets through directed evolution experiments. A challenge is that many resistance genes hide in a noisy mutational background as mutator clones emerge in the adaptive population. Here, to overcome this noise, we quantify the impact of...

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Detalles Bibliográficos
Autores principales: Marciano, David C., Wang, Chen, Hsu, Teng-Kuei, Bourquard, Thomas, Atri, Benu, Nehring, Ralf B., Abel, Nicholas S., Bowling, Elizabeth A., Chen, Taylor J., Lurie, Pamela D., Katsonis, Panagiotis, Rosenberg, Susan M., Herman, Christophe, Lichtarge, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184624/
https://www.ncbi.nlm.nih.gov/pubmed/35680894
http://dx.doi.org/10.1038/s41467-022-30889-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184624/
https://www.ncbi.nlm.nih.gov/pubmed/35680894
http://dx.doi.org/10.1038/s41467-022-30889-1

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