Whole Genome Sequencing Identifies Novel Mutations Associated With Bedaquiline Resistance in Mycobacterium tuberculosis

Bedaquiline (BDQ), a new antitubercular agent, has been used to treat drug-resistant tuberculosis (TB). Although mutations in atpE, rv0678, and pepQ confer major resistance to BDQ, the mechanisms of resistance to BDQ in vitro and in clinical settings have not been fully elucidated. We selected BDQ-r...

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Detalles Bibliográficos
Autores principales: Guo, Qinglong, Bi, Jing, Lin, Qiao, Ye, Taosheng, Wang, Zhongyuan, Wang, Zhaoqin, Liu, Lei, Zhang, Guoliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184757/
https://www.ncbi.nlm.nih.gov/pubmed/35694543
http://dx.doi.org/10.3389/fcimb.2022.807095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184757/
https://www.ncbi.nlm.nih.gov/pubmed/35694543
http://dx.doi.org/10.3389/fcimb.2022.807095

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