Synergistic engineering of CRISPR-Cas nucleases enables robust mammalian genome editing

The naturally occurring prokaryotic CRISPR-Cas systems provide valuable resources for the development of new genome-editing tools. However, the majority of prokaryotic Cas nucleases exhibit poor editing efficiency in mammalian cells, which significantly limits their utility. Here, we have developed...

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Detalles Bibliográficos
Autores principales: Chen, Yangcan, Hu, Yanping, Wang, Xinge, Luo, Shengqiu, Yang, Ning, Chen, Yi, Li, Zhikun, Zhou, Qi, Li, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184807/
https://www.ncbi.nlm.nih.gov/pubmed/35693153
http://dx.doi.org/10.1016/j.xinn.2022.100264

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184807/
https://www.ncbi.nlm.nih.gov/pubmed/35693153
http://dx.doi.org/10.1016/j.xinn.2022.100264

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