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Multi-omics profiling of single nuclei from frozen archived postmortem human pituitary tissue
Concomitant profiling of transcriptome and chromatin accessibility in isolated nuclei can reveal gene regulatory control mechanisms in health and disease. We report a single nucleus multi-omics analysis protocol optimized for frozen archived postmortem human pituitaries that is also effective for fr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184808/ https://www.ncbi.nlm.nih.gov/pubmed/35693209 http://dx.doi.org/10.1016/j.xpro.2022.101446 |