Ancestral Sequence Reconstruction of a Cytochrome P450 Family Involved in Chemical Defense Reveals the Functional Evolution of a Promiscuous, Xenobiotic-Metabolizing Enzyme in Vertebrates

The cytochrome P450 family 1 enzymes (CYP1s) are a diverse family of hemoprotein monooxygenases, which metabolize many xenobiotics including numerous environmental carcinogens. However, their historical function and evolution remain largely unstudied. Here we investigate CYP1 evolution via the recon...

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Detalles Bibliográficos
Autores principales: Harris, Kurt L., Thomson, Raine E.S., Gumulya, Yosephine, Foley, Gabriel, Carrera-Pacheco, Saskya E., Syed, Parnayan, Janosik, Tomasz, Sandinge, Ann-Sofie, Andersson, Shalini, Jurva, Ulrik, Bodén, Mikael, Gillam, Elizabeth M.J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Discoveries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185370/
https://www.ncbi.nlm.nih.gov/pubmed/35639613
http://dx.doi.org/10.1093/molbev/msac116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185370/
https://www.ncbi.nlm.nih.gov/pubmed/35639613
http://dx.doi.org/10.1093/molbev/msac116

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