Characterization of SARS-CoV-2 replication complex elongation and proofreading activity

The replication complex (RC) of SARS-CoV-2 was recently shown to be one of the fastest RNA-dependent RNA polymerases of any known coronavirus. With this rapid elongation, the RC is more prone to incorporate mismatches during elongation, resulting in a highly variable genomic sequence. Such mutations...

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Detalles Bibliográficos
Autores principales: Jones, Alisha N., Mourão, André, Czarna, Anna, Matsuda, Alex, Fino, Roberto, Pyrc, Krzysztof, Sattler, Michael, Popowicz, Grzegorz M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185715/
https://www.ncbi.nlm.nih.gov/pubmed/35688849
http://dx.doi.org/10.1038/s41598-022-13380-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185715/
https://www.ncbi.nlm.nih.gov/pubmed/35688849
http://dx.doi.org/10.1038/s41598-022-13380-1

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