Epitope Mapping and Binding Assessment by Solid-State NMR Provide a Way for the Development of Biologics under the Quality by Design Paradigm

[Image: see text] Multispecific biologics are an emerging class of drugs, in which antibodies and/or proteins designed to bind pharmacological targets are covalently linked or expressed as fusion proteins to increase both therapeutic efficacy and safety. Epitope mapping on the target proteins provid...

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Detalles Bibliográficos
Autores principales: Rizzo, Domenico, Cerofolini, Linda, Giuntini, Stefano, Iozzino, Luisa, Pergola, Carlo, Sacco, Francesca, Palmese, Angelo, Ravera, Enrico, Luchinat, Claudio, Baroni, Fabio, Fragai, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185746/
https://www.ncbi.nlm.nih.gov/pubmed/35617699
http://dx.doi.org/10.1021/jacs.2c03232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185746/
https://www.ncbi.nlm.nih.gov/pubmed/35617699
http://dx.doi.org/10.1021/jacs.2c03232

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