Cargando…

Sodium(+)/taurocholate cotransporting polypeptide as target therapy for liver fibrosis

OBJECTIVE: Sodium(+)/ taurocholate cotransporting polypeptide (NTCP) is a membrane transporter affecting the enterohepatic circulation of bile acids (BAs). We aimed to evaluate NTCP’s roles in humans and animal models of liver fibrosis (LF). DESIGN: Primary hepatic stellate cells (pHSCs) isolated fr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Salhab, Ahmad, Amer, Johnny, Lu, Yinying, Safadi, Rifaat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2022
Materias:	Hepatology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185811/ https://www.ncbi.nlm.nih.gov/pubmed/34266968 http://dx.doi.org/10.1136/gutjnl-2020-323345

Ejemplares similares

25(OH) D3 alleviate liver NK cytotoxicity in acute but not in chronic fibrosis model of BALB/c mice due to modulations in vitamin D receptor
por: Salhab, Ahmad, et al.
Publicado: (2020)

Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide
por: Witzigmann, Dominik, et al.
Publicado: (2019)

Age‐dependent glycosylation of the sodium taurocholate cotransporter polypeptide: From fetal to adult human livers
por: Sargiacomo, Camillo, et al.
Publicado: (2018)

Clinical and histopathologic features of sodium taurocholate cotransporting polypeptide deficiency in pediatric patients
por: Dong, Chen, et al.
Publicado: (2019)

Clinical and molecular study of a pediatric patient with sodium taurocholate cotransporting polypeptide deficiency
por: Deng, Mei, et al.
Publicado: (2016)

Blocking Sodium‐Taurocholate Cotransporting Polypeptide Stimulates Biliary Cholesterol and Phospholipid Secretion in Mice
por: Roscam Abbing, Reinout L.P., et al.
Publicado: (2019)

Effect of mTOR inhibitors on sodium taurocholate cotransporting polypeptide (NTCP) function in vitro
por: Saran, Chitra, et al.
Publicado: (2023)

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
por: Yan, Huan, et al.
Publicado: (2012)

Troglitazone Impedes the Oligomerization of Sodium Taurocholate Cotransporting Polypeptide and Entry of Hepatitis B Virus Into Hepatocytes
por: Fukano, Kento, et al.
Publicado: (2019)

Monozygotic Twins Suffering From Sodium Taurocholate Cotransporting Polypeptide Deficiency: A Case Report
por: Tan, Hui-Jun, et al.
Publicado: (2018)

Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver
por: Nakabori, Tasuku, et al.
Publicado: (2016)

The Immune Interplay between Thyroid Papillary Carcinoma and Hepatic Fibrosis
por: Muhanna, Nidal, et al.
Publicado: (2015)

Correction: Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
por: Yan, Huan, et al.
Publicado: (2014)

Hepatocytic expression of human sodium-taurocholate cotransporting polypeptide enables hepatitis B virus infection of macaques
por: Burwitz, Benjamin J., et al.
Publicado: (2017)

Clinical features of sodium-taurocholate cotransporting polypeptide deficiency in pediatric patients: case series and literature review
por: Zou, Ting-Ting, et al.
Publicado: (2021)

Upregulation of HBV transcription by sodium taurocholate cotransporting polypeptide at the postentry step is inhibited by the entry inhibitor Myrcludex B
por: Zhao, Kaitao, et al.
Publicado: (2018)

Na(+)‐taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice
por: Slijepcevic, Davor, et al.
Publicado: (2018)

Hepatic Expression of the Na(+)-Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation
por: Tremmel, Roman, et al.
Publicado: (2022)

Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
por: Miyakawa, Kei, et al.
Publicado: (2018)

Chemical array system, a platform to identify novel hepatitis B virus entry inhibitors targeting sodium taurocholate cotransporting polypeptide
por: Kaneko, Manabu, et al.
Publicado: (2018)

Hepatitis B virus efficiently infects non-adherent hepatoma cells via human sodium taurocholate cotransporting polypeptide
por: Okuyama-Dobashi, Kaori, et al.
Publicado: (2015)

Sodium Taurocholate Cotransporting Polypeptide (NTCP) Deficiency Hidden Behind Citrin Deficiency in Early Infancy: A Report of Three Cases
por: Lin, Hui, et al.
Publicado: (2019)

De novo mutation loci and clinical analysis in a child with sodium taurocholate cotransport polypeptide deficiency: A case report
por: Liu, Hui-Yan, et al.
Publicado: (2021)

Calnexin Depletion by Endoplasmic Reticulum Stress During Cholestasis Inhibits the Na(+)‐Taurocholate Cotransporting Polypeptide
por: Robin, Marion J.D., et al.
Publicado: (2018)

Structural Plasticity Is a Feature of Rheostat Positions in the Human Na(+)/Taurocholate Cotransporting Polypeptide (NTCP)
por: Ruggiero, Melissa J., et al.
Publicado: (2022)

Lack of Ser267Phe variant of sodium taurocholate cotransporting polypeptide among Moroccans regardless of hepatitis B virus infection status
por: Ezzikouri, Sayeh, et al.
Publicado: (2017)

E-cadherin Plays a Role in Hepatitis B Virus Entry Through Affecting Glycosylated Sodium-Taurocholate Cotransporting Polypeptide Distribution
por: Hu, Qin, et al.
Publicado: (2020)

Specific Binding and Endocytosis of Liposomes to HEK293T Cells via Myrisoylated Pre-S1 Peptide Bound to Sodium Taurocholate Cotransporting Polypeptide
por: Hinuma, Shuji, et al.
Publicado: (2022)

A clinically relevant polymorphism in the Na(+)/taurocholate cotransporting polypeptide (NTCP) occurs at a rheostat position
por: Ruggiero, Melissa J., et al.
Publicado: (2020)

Primary Biliary Acids Inhibit Hepatitis D Virus (HDV) Entry into Human Hepatoma Cells Expressing the Sodium-Taurocholate Cotransporting Polypeptide (NTCP)
por: Veloso Alves Pereira, Isabel, et al.
Publicado: (2015)

Upregulation of sodium taurocholate cotransporter polypeptide during hepatogenic differentiation of umbilical cord matrix mesenchymal stem cells facilitates hepatitis B entry
por: Sargiacomo, Camillo, et al.
Publicado: (2017)

Multitasking Na(+)/Taurocholate Cotransporting Polypeptide (NTCP) as a Drug Target for HBV Infection: From Protein Engineering to Drug Discovery
por: Zakrzewicz, Dariusz, et al.
Publicado: (2022)

The Lipid Raft Component Stomatin Interacts with the Na(+) Taurocholate Cotransporting Polypeptide (NTCP) and Modulates Bile Salt Uptake
por: Appelman, Monique D., et al.
Publicado: (2020)

Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter, sodium taurocholate cotransporting polypeptide (NTCP)
por: Watashi, Koichi, et al.
Publicado: (2014)

Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice
por: Slijepcevic, Davor, et al.
Publicado: (2017)

Insulin signaling as a potential natural killer cell checkpoint in fatty liver disease
por: Amer, Johnny, et al.
Publicado: (2018)

Loss of hepatic Mboat7 leads to liver fibrosis
por: Thangapandi, Veera Raghavan, et al.
Publicado: (2021)

Validation of Novel Fibrosis Index (NFI) for assessment of liver fibrosis: comparison with transient elastography (FibroScan)
por: Hussain, Azhar, et al.
Publicado: (2019)

Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells
por: Dai, Zhen, et al.
Publicado: (2020)

Accurate liquid biopsy for the diagnosis of non-alcoholic steatohepatitis and liver fibrosis
por: Angelini, Giulia, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n3uaf2je2l5r9epnekogrgh35e