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Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology

BACKGROUND: The Bcl-3 protein is an atypical member of the inhibitor of -κB family that has dual roles as a transcriptional repressor and a coactivator for dimers of NF-κB p50 and p52. Bcl-3 is expressed in mammary adenocarcinomas and can promote tumorigenesis and survival signaling and has a key ro...

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Detalles Bibliográficos
Autores principales: Carr, David, Zein, Aiman, Coulombe, Josée, Jiang, Tianqi, Cabrita, Miguel A., Ward, Gwendoline, Daneshmand, Manijeh, Sau, Andrea, Pratt, M. A. Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185916/
https://www.ncbi.nlm.nih.gov/pubmed/35681213
http://dx.doi.org/10.1186/s13058-022-01536-w