Scientific rationale for a higher dose of nusinersen

OBJECTIVE: The long‐term favorable safety profile of nusinersen provides an opportunity to consider a higher dose. We report on the relationships between nusinersen cerebrospinal fluid (CSF) exposure, biomarker levels, and clinical efficacy. METHODS: The analyses used data from the CS3A and ENDEAR s...

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Detalles Bibliográficos
Autores principales: Finkel, Richard S., Ryan, Monique M., Pascual Pascual, Samuel Ignacio, Day, John W., Mercuri, Eugenio, De Vivo, Darryl C., Foster, Richard, Montes, Jacqueline, Gurgel‐Giannetti, Juliana, MacCannell, Drew, Berger, Zdenek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186144/
https://www.ncbi.nlm.nih.gov/pubmed/35567345
http://dx.doi.org/10.1002/acn3.51562

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186144/
https://www.ncbi.nlm.nih.gov/pubmed/35567345
http://dx.doi.org/10.1002/acn3.51562

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