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The transformation of atrial fibroblasts into myofibroblasts is promoted by trimethylamine N-oxide via the Wnt3a/β-catenin signaling pathway

BACKGROUND: Atrial fibrosis is an important pathophysiological mechanism in the development and maintenance of atrial fibrillation. Trimethylamine N-oxide (TMAO) is one of the most widely studied microbial metabolites involved in the promotion of cardiac fibrosis. TMAO promotes phenotypic transforma...

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Detalles Bibliográficos
Autores principales: Yang, Wentao, Zhao, Qing, Yao, Minghui, Li, Xiangdong, Shan, Zhaoliang, Wang, Yutang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186223/
https://www.ncbi.nlm.nih.gov/pubmed/35693618
http://dx.doi.org/10.21037/jtd-22-475