Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin: In-Silico Based Study

BACKGROUND: Thyroid hormones (TH), T4 and T3, mediate pro-mitogenic effects in cancer cells through binding the membrane receptor αvβ3 integrin. The deaminated analogue tetrac effectively blocks TH binding to this receptor and prevents their action. While computational data on TH binding to the αvβ3...

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Detalles Bibliográficos
Autores principales: Tobi, Dror, Krashin, Eilon, Davis, Paul J., Cody, Vivian, Ellis, Martin, Ashur-Fabian, Osnat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186291/
https://www.ncbi.nlm.nih.gov/pubmed/35692387
http://dx.doi.org/10.3389/fendo.2022.895240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186291/
https://www.ncbi.nlm.nih.gov/pubmed/35692387
http://dx.doi.org/10.3389/fendo.2022.895240

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