Development of a Generic Physiologically Based Kinetic Model to Predict In Vivo Uterotrophic Responses Induced by Estrogenic Chemicals in Rats Based on In Vitro Bioassays

The present study assessed the potential of a generic physiologically based kinetic (PBK) model to convert in vitro data for estrogenicity to predict the in vivo uterotrophic response in rats for diethylstibestrol (DES), ethinylestradiol (EE2), genistein (GEN), coumestrol (COU), and methoxychlor (MX...

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Detalles Bibliográficos
Autores principales: Zhang, Mengying, van Ravenzwaay, Bennard, Rietjens, Ivonne M C M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Computational Toxicology and Databases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186316/
https://www.ncbi.nlm.nih.gov/pubmed/31626307
http://dx.doi.org/10.1093/toxsci/kfz216

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186316/
https://www.ncbi.nlm.nih.gov/pubmed/31626307
http://dx.doi.org/10.1093/toxsci/kfz216

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