Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

Emerging drug resistance is generating an urgent need for novel and effective antibiotics. A promising target that has not yet been addressed by approved antibiotics is the bacterial DNA gyrase subunit B (GyrB), and GyrB inhibitors could be effective against drug-resistant bacteria, such as methicil...

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Detalles Bibliográficos
Autores principales: Xue, Wenjie, Wang, Yaling, Lian, Xu, Li, Xueyao, Pang, Jing, Kirchmair, Johannes, Wu, Kebin, Han, Zunsheng, You, Xuefu, Zhang, Hongmin, Xia, Jie, Wu, Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186351/
https://www.ncbi.nlm.nih.gov/pubmed/36278813
http://dx.doi.org/10.1080/14756366.2022.2084088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186351/
https://www.ncbi.nlm.nih.gov/pubmed/36278813
http://dx.doi.org/10.1080/14756366.2022.2084088

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