Design and biological evaluation of substituted 5,7-dihydro-6H-indolo[2,3-c]quinolin-6-one as novel selective Haspin inhibitors

A library of substituted indolo[2,3-c]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, and a reduction/lactamization sequence. The inhibitory activit...

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Detalles Bibliográficos
Autores principales: Avula, Sreenivas, Peng, Xudan, Lang, Xingfen, Tortorella, Micky, Josselin, Béatrice, Bach, Stéphane, Bourg, Stephane, Bonnet, Pascal, Buron, Frédéric, Ruchaud, Sandrine, Routier, Sylvain, Neagoie, Cleopatra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186362/
https://www.ncbi.nlm.nih.gov/pubmed/35670091
http://dx.doi.org/10.1080/14756366.2022.2082419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186362/
https://www.ncbi.nlm.nih.gov/pubmed/35670091
http://dx.doi.org/10.1080/14756366.2022.2082419

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