Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization

PURPOSE: Risk of advanced age-related macular degeneration (AAMD) is associated with rare genetic variants in the gene encoding complement factor I (CFI), which is associated with lower circulating CFI protein levels, but the nature of the relationship is unclear. Can genetic factors be used to infe...

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Detalles Bibliográficos
Autores principales: Jones, Amy V., MacGregor, Stuart, Han, Xikun, Francis, James, Harris, Claire, Kavanagh, David, Lotery, Andrew, Waheed, Nadia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186402/
https://www.ncbi.nlm.nih.gov/pubmed/35693873
http://dx.doi.org/10.1016/j.xops.2022.100146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186402/
https://www.ncbi.nlm.nih.gov/pubmed/35693873
http://dx.doi.org/10.1016/j.xops.2022.100146

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