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Evaluating a Causal Relationship between Complement Factor I Protein Level and Advanced Age-Related Macular Degeneration Using Mendelian Randomization

PURPOSE: Risk of advanced age-related macular degeneration (AAMD) is associated with rare genetic variants in the gene encoding complement factor I (CFI), which is associated with lower circulating CFI protein levels, but the nature of the relationship is unclear. Can genetic factors be used to infe...

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Detalles Bibliográficos
Autores principales:	Jones, Amy V., MacGregor, Stuart, Han, Xikun, Francis, James, Harris, Claire, Kavanagh, David, Lotery, Andrew, Waheed, Nadia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186402/ https://www.ncbi.nlm.nih.gov/pubmed/35693873 http://dx.doi.org/10.1016/j.xops.2022.100146

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