Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism

Previous studies have shown that the polyamine spermidine increased the maximum life span in C. elegans and the median life span in mice. Since spermidine increases autophagy, we asked if treatment with chloroquine, an inhibitor of autophagy, would shorten the lifespan of mice. Recently, chloroquine...

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Detalles Bibliográficos
Autores principales: Doeppner, Thorsten R., Coman, Cristin, Burdusel, Daiana, Ancuta, Diana-Larisa, Brockmeier, Ulf, Pirici, Daniel Nicolae, Yaoyun, Kuang, Hermann, Dirk M., Popa-Wagner, Aurel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186778/
https://www.ncbi.nlm.nih.gov/pubmed/35609021
http://dx.doi.org/10.18632/aging.204069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186778/
https://www.ncbi.nlm.nih.gov/pubmed/35609021
http://dx.doi.org/10.18632/aging.204069

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