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Genome-wide cross-cancer analysis illustrates the critical role of bimodal miRNA in patient survival and drug responses to PI3K inhibitors

Heterogeneity of cancer means many tumorigenic genes are only aberrantly expressed in a subset of patients and thus follow a bimodal distribution, having two modes of expression within a single population. Traditional statistical techniques that compare sample means between cancer patients and healt...

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Detalles Bibliográficos
Autores principales: Moody, Laura, Xu, Guanying Bianca, Pan, Yuan-Xiang, Chen, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187341/
https://www.ncbi.nlm.nih.gov/pubmed/35639779
http://dx.doi.org/10.1371/journal.pcbi.1010109