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SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans

BACKGROUND: Solute carrier family 26 member (SLC26A9) is a Cl(−) uniporter with very high expression levels in the gastric mucosa. Here, we describe morphological and molecular alterations in gastric mucosa of slc26a9(−/−) mice and in selective parietal cell-deleted slc26a9(fl/fl)/Atp4b-Cre mice and...

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Detalles Bibliográficos
Autores principales: Liu, Xuemei, Li, Taolang, Ma, Zhiyuan, Riederer, Brigitte, Yuan, Dumin, Zhu, Jiaxing, Li, Yunhua, An, Jiaxing, Wen, Guorong, Jin, Hai, Yang, Xiao, Seidler, Ursula, Tuo, Biguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187568/
https://www.ncbi.nlm.nih.gov/pubmed/35426084
http://dx.doi.org/10.1007/s13402-022-00672-x