Inhibition of myeloid-derived suppressive cell function with all-trans retinoic acid enhanced anti-PD-L1 efficacy in cervical cancer

PD-1/PD-L1 inhibitor treatments are relatively inefficacious in advanced cervical cancer patients. The presence of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment may be one significant barrier to efficacy. It has been shown that all-trans retinoic acid (ATRA) can differentiat...

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Detalles Bibliográficos
Autores principales: Liang, Yun, Wang, Wenshan, Zhu, Xiaojun, Yu, Minghua, Zhou, Caiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187659/
https://www.ncbi.nlm.nih.gov/pubmed/35688951
http://dx.doi.org/10.1038/s41598-022-13855-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187659/
https://www.ncbi.nlm.nih.gov/pubmed/35688951
http://dx.doi.org/10.1038/s41598-022-13855-1

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