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Inhibition of myeloid-derived suppressive cell function with all-trans retinoic acid enhanced anti-PD-L1 efficacy in cervical cancer

PD-1/PD-L1 inhibitor treatments are relatively inefficacious in advanced cervical cancer patients. The presence of myeloid-derived suppressor cells (MDSCs) in the tumor microenvironment may be one significant barrier to efficacy. It has been shown that all-trans retinoic acid (ATRA) can differentiat...

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Detalles Bibliográficos
Autores principales:	Liang, Yun, Wang, Wenshan, Zhu, Xiaojun, Yu, Minghua, Zhou, Caiyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187659/ https://www.ncbi.nlm.nih.gov/pubmed/35688951 http://dx.doi.org/10.1038/s41598-022-13855-1

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