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Mirror-image streptavidin with specific binding to L-biotin, the unnatural enantiomer

The streptavidin–biotin system is known to have a very high affinity and specificity and is widely used in biochemical immunoassays and diagnostics. However, this method is affected by endogenous D-biotin in serum sample measurements (biotin interference). While several efforts using alternative hig...

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Detalles Bibliográficos
Autores principales: Suganuma, Masatoshi, Kubo, Takuya, Ishiki, Kengo, Tanaka, Kota, Suto, Kouzou, Ejima, Daisuke, Toyota, Masahiro, Tsumoto, Kouhei, Sato, Toshiyuki, Nishikawa, Youichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187662/
https://www.ncbi.nlm.nih.gov/pubmed/35688934
http://dx.doi.org/10.1038/s41598-022-13763-4