DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage

This study used DNA methyltransferase 3b (DNMT3b) knockout cells and the functional loss of DNMT3b mutation in immunodeficiency-centromeric instability-facial anomalies syndrome (ICF) cells to understand how DNMT3b dysfunction causes genome instability. We demonstrated that R-loops contribute to DNA...

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Detalles Bibliográficos
Autores principales: Shih, Hsueh-Tzu, Chen, Wei-Yi, Wang, Hsin-Yen, Chao, Tung, Huang, Hsien-Da, Chou, Chih-Hung, Chang, Zee-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187704/
https://www.ncbi.nlm.nih.gov/pubmed/35688824
http://dx.doi.org/10.1038/s41419-022-04989-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187704/
https://www.ncbi.nlm.nih.gov/pubmed/35688824
http://dx.doi.org/10.1038/s41419-022-04989-1

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