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DNMT3b protects centromere integrity by restricting R-loop-mediated DNA damage
This study used DNA methyltransferase 3b (DNMT3b) knockout cells and the functional loss of DNMT3b mutation in immunodeficiency-centromeric instability-facial anomalies syndrome (ICF) cells to understand how DNMT3b dysfunction causes genome instability. We demonstrated that R-loops contribute to DNA...
Autores principales: | Shih, Hsueh-Tzu, Chen, Wei-Yi, Wang, Hsin-Yen, Chao, Tung, Huang, Hsien-Da, Chou, Chih-Hung, Chang, Zee-Fen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187704/ https://www.ncbi.nlm.nih.gov/pubmed/35688824 http://dx.doi.org/10.1038/s41419-022-04989-1 |
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