Cargando…

Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells

PURPOSE: Secreted protein, acidic and rich in cysteine (SPARC) elevates intraocular pressure (IOP), increases certain structural extracellular matrix (ECM) proteins in the juxtacanalicular trabecular meshwork (JCT), and decreases matrix metalloproteinase (MMP) protein levels in trabecular meshwork (...

Descripción completa

Detalles Bibliográficos
Autores principales:	MacDonald, William W., Swaminathan, Swarup S., Heo, Jae Young, Castillejos, Alexandra, Hsueh, Jessica, Liu, Brian J., Jo, Diane, Du, Annie, Lee, Hyunpil, Kang, Min Hyung, Rhee, Douglas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187959/ https://www.ncbi.nlm.nih.gov/pubmed/35671048 http://dx.doi.org/10.1167/iovs.63.6.8

Ejemplares similares

A Porcine Anterior Segment Perfusion and Transduction Model With Direct Visualization of the Trabecular Meshwork
por: Loewen, Ralitsa T., et al.
Publicado: (2016)

Endoplasmic Reticulum Stress Response of Trabecular Meshwork Stem Cells and Trabecular Meshwork Cells and Protective Effects of Activated PERK Pathway
por: Wang, Yiwen, et al.
Publicado: (2019)

Morphology of the Trabecular Meshwork and Schlemm's Canal in Posner-Schlossman Syndrome
por: Yan, Xiaoqin, et al.
Publicado: (2022)

Inhibition of TGF-β2–Induced Trabecular Meshwork Fibrosis by Pirfenidone
por: Zhu, Xiaofeng, et al.
Publicado: (2023)

TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology
por: Ashok, Ajay, et al.
Publicado: (2020)

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2018)

Proteasome Inhibition Increases the Efficiency of Lentiviral Vector-Mediated Transduction of Trabecular Meshwork
por: Aktas, Zeynep, et al.
Publicado: (2018)

Estimating Human Trabecular Meshwork Stiffness by Numerical Modeling and Advanced OCT Imaging
por: Wang, Ke, et al.
Publicado: (2017)

Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells
por: Sun, Ying Ying, et al.
Publicado: (2019)

Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells
por: Keller, Kate E., et al.
Publicado: (2017)

Effects of Lentivirus-Mediated C3 Expression on Trabecular Meshwork Cells and Intraocular Pressure
por: Tan, Junka, et al.
Publicado: (2018)

The Molecular Processes in the Trabecular Meshwork After Exposure to Corticosteroids and in Corticosteroid-Induced Ocular Hypertension
por: Liesenborghs, Ilona, et al.
Publicado: (2020)

HDAC Inhibitor-Mediated Epigenetic Regulation of Glaucoma-Associated TGFβ2 in the Trabecular Meshwork
por: Bermudez, Jaclyn Y., et al.
Publicado: (2016)

Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation
por: Sun, Ying Ying, et al.
Publicado: (2019)

Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype
por: Dhamodaran, Kamesh, et al.
Publicado: (2020)

Osthole Reduces Mouse IOP Associated With Ameliorating Extracellular Matrix Expression of Trabecular Meshwork Cell
por: Fan, Yuchen, et al.
Publicado: (2020)

Expression of Mutant Myocilin Induces Abnormal Intracellular Accumulation of Selected Extracellular Matrix Proteins in the Trabecular Meshwork
por: Kasetti, Ramesh B., et al.
Publicado: (2016)

Crosstalk Between Transforming Growth Factor Beta-2 and Toll-Like Receptor 4 in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2017)

A Porcine Organ-Culture Glaucoma Model Mimicking Trabecular Meshwork Damage Using Oxidative Stress
por: Snider, Eric J., et al.
Publicado: (2021)

Growth Differentiation Factor-15–Induced Contractile Activity and Extracellular Matrix Production in Human Trabecular Meshwork Cells
por: Muralidharan, Arumugam Ramachandran, et al.
Publicado: (2016)

Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch
por: Youngblood, Hannah, et al.
Publicado: (2020)

Lysophosphatidic Acid Induces ECM Production via Activation of the Mechanosensitive YAP/TAZ Transcriptional Pathway in Trabecular Meshwork Cells
por: Ho, Leona T. Y., et al.
Publicado: (2018)

The Effect of Dietary Vitamin K1 Supplementation on Trabecular Meshwork and Retina in a Chronic Ocular Hypertensive Rat Model
por: Deng, Chaohua, et al.
Publicado: (2020)

Dexamethasone and Glucocorticoid-Induced Matrix Temporally Modulate Key Integrins, Caveolins, Contractility, and Stiffness in Human Trabecular Meshwork Cells
por: Yemanyi, Felix, et al.
Publicado: (2020)

Aberrant Collagen Composition of the Trabecular Meshwork Results in Reduced Aqueous Humor Drainage and Elevated IOP in MMP-9 Null Mice
por: De Groef, Lies, et al.
Publicado: (2016)

Crosslinked Extracellular Matrix Stiffens Human Trabecular Meshwork Cells Via Dysregulating β-catenin and YAP/TAZ Signaling Pathways
por: Yemanyi, Felix, et al.
Publicado: (2020)

TGF-β2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression
por: Rao, Vidhya R., et al.
Publicado: (2021)

Reduced Pulsatile Trabecular Meshwork Motion in Eyes With Primary Open Angle Glaucoma Using Phase-Sensitive Optical Coherence Tomography
por: Gao, Kai, et al.
Publicado: (2020)

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma
por: Zhu, Wei, et al.
Publicado: (2017)

Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner
por: Filla, Mark S., et al.
Publicado: (2019)

Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells
por: Yemanyi, Felix, et al.
Publicado: (2020)

iPSC-Derived Trabecular Meshwork Cells Stimulate Endogenous TM Cell Division Through Gap Junction in a Mouse Model of Glaucoma
por: Sui, Shangru, et al.
Publicado: (2021)

TGFβ2 Induces the Formation of Cross-Linked Actin Networks (CLANs) in Human Trabecular Meshwork Cells Through the Smad and Non-Smad Dependent Pathways
por: Montecchi-Palmer, Michela, et al.
Publicado: (2017)

Agreement of Anterior Segment Parameters Obtained From Swept-Source Fourier-Domain and Time-Domain Anterior Segment Optical Coherence Tomography
por: Chansangpetch, Sunee, et al.
Publicado: (2018)

Analysis of interleukin-20 receptor complexes in trabecular meshwork cells and effects of cytokine signaling in anterior segment perfusion culture
por: Keller, Kate E., et al.
Publicado: (2019)

Diagnostic performance of anterior segment optical coherence tomography in detecting plateau iris
por: Wanichwecharungruang, Boonsong, et al.
Publicado: (2022)

Tissue-engineered anterior segment eye cultures demonstrate hallmarks of conventional organ culture
por: Waxman, Susannah, et al.
Publicado: (2022)

Occurrence of Oxidative Stress and Premature Senescence in the Anterior Segment of Acute Primary Angle-Closure Eyes
por: Ye, Dan, et al.
Publicado: (2022)

Aqueous Angiography–Mediated Guidance of Trabecular Bypass Improves Angiographic Outflow in Human Enucleated Eyes
por: Huang, Alex S., et al.
Publicado: (2016)

Transduction Pattern of AAVs in the Trabecular Meshwork and Anterior-Segment Structures in a Rat Model of Ocular Hypertension
por: Lee, Si Hyung, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_h435j44rac85qj19o8n5v1kfh1