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Contrastive learning on protein embeddings enlightens midnight zone

Experimental structures are leveraged through multiple sequence alignments, or more generally through homology-based inference (HBI), facilitating the transfer of information from a protein with known annotation to a query without any annotation. A recent alternative expands the concept of HBI from...

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Detalles Bibliográficos
Autores principales: Heinzinger, Michael, Littmann, Maria, Sillitoe, Ian, Bordin, Nicola, Orengo, Christine, Rost, Burkhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188115/
https://www.ncbi.nlm.nih.gov/pubmed/35702380
http://dx.doi.org/10.1093/nargab/lqac043