Efficient adoptive transfer of autologous modified B cells: a new humanized platform mouse model for testing B cells reprogramming therapies

Here, we report a novel experimental setup to perform adoptive transfer of gene-edited B cells using humanized immune system mice by infusing autologous HIS mouse-derived human B cells “educated” in a murine context and thus rendered tolerant to the host. The present approach presents two advantages...

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Detalles Bibliográficos
Autores principales: Page, Audrey, Laurent, Emilie, Nègre, Didier, Costa, Caroline, Pierre, Véronique, Defrance, Thierry, Cosset, François-Loïc, Fusil, Floriane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188505/
https://www.ncbi.nlm.nih.gov/pubmed/34748076
http://dx.doi.org/10.1007/s00262-021-03101-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188505/
https://www.ncbi.nlm.nih.gov/pubmed/34748076
http://dx.doi.org/10.1007/s00262-021-03101-4

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