Constitutive androstane receptor and pregnane X receptor genotype influence efavirenz plasma concentration and CYP2B6 enzyme activity

Efavirenz is metabolized by CYP2B6, an inducible enzyme whose expression is regulated by the constitutive androstane receptor and pregnane X receptor nuclear receptors. CAR and PXR are encoded by genetically polymorphic NR1I2 and NR1I3, respectively. We examined the impact of NR1I2 and NR1I3 genotyp...

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Detalles Bibliográficos
Autores principales: Petros, Zelalem, Habtewold, Abiy, Makonnen, Eyasu, Aklillu, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188543/
https://www.ncbi.nlm.nih.gov/pubmed/35690682
http://dx.doi.org/10.1038/s41598-022-14032-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188543/
https://www.ncbi.nlm.nih.gov/pubmed/35690682
http://dx.doi.org/10.1038/s41598-022-14032-0

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