Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain

Metformin is a well-tolerated antidiabetic drug and has recently been repurposed for numerous diseases, including pain. However, a higher dose of metformin is required for effective analgesia, which can potentiate its dose-dependent gastrointestinal side effects. Curcumin is a natural polyphenol and...

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Detalles Bibliográficos
Autores principales: Dasuni Wasana, Peththa Wadu, Hasriadi, Muangnoi, Chawanphat, Vajragupta, Opa, Rojsitthisak, Pranee, Rojsitthisak, Pornchai, Towiwat, Pasarapa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188603/
https://www.ncbi.nlm.nih.gov/pubmed/35690654
http://dx.doi.org/10.1038/s41598-022-13647-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188603/
https://www.ncbi.nlm.nih.gov/pubmed/35690654
http://dx.doi.org/10.1038/s41598-022-13647-7

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