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Fibronectin containing alternatively spliced extra domain A interacts at the central and c-terminal domain of Toll-like receptor-4

Extra domain A of cellular fibronectin (FN-EDA) is known to cause insulin resistance, atherosclerosis, tissue fibrosis, ischemic stroke and exaggerated myocardial reperfusion injury through Toll-like receptor 4 (TLR4). However, the FN-EDA-TLR4 interacting site is not well established. Therefore, in-...

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Detalles Bibliográficos
Autores principales: Gupta, Shubhangi, Ali, Azeem, Pandey, Saurabh, Khan, Imran A., Prakash, Prem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188610/
https://www.ncbi.nlm.nih.gov/pubmed/35690624
http://dx.doi.org/10.1038/s41598-022-13622-2