A Phase 1, Open-Label Study to Evaluate the Effects of Food and Evening Dosing on the Pharmacokinetics of Oral Trofinetide in Healthy Adult Subjects

BACKGROUND AND OBJECTIVE: Trofinetide, a synthetic analog of tripeptide glycine-proline-glutamate, is an investigational agent for the treatment of Rett syndrome, a neurodevelopmental disorder with affected individuals requiring lifelong support. Food can affect the pharmacokinetic profile of a drug...

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Detalles Bibliográficos
Autores principales: Darwish, Mona, Youakim, James M., Harlick, Jim, DeKarske, Daryl, Stankovic, Serge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188616/
https://www.ncbi.nlm.nih.gov/pubmed/35622206
http://dx.doi.org/10.1007/s40261-022-01156-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188616/
https://www.ncbi.nlm.nih.gov/pubmed/35622206
http://dx.doi.org/10.1007/s40261-022-01156-4

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