Cargando…

Targeting SARS-CoV-2 non-structural protein 13 via helicase-inhibitor-repurposing and non-structural protein 16 through pharmacophore-based screening

Novel drug compound hunting was carried out for SARS-CoV-2 proteins with low mutation susceptibility. The probability of escape mutation and drug resistance is lower if conserved microbial proteins are targeted by therapeutic drugs. Mutation rate of all SARS-CoV-2 proteins were analyzed via multiple...

Descripción completa

Detalles Bibliográficos
Autores principales:	Samdani, Md. Nazmus, Morshed, Niaz, Reza, Rumman, Asaduzzaman, Muhammad, Islam, Abul Bashar Mir Md. Khademul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188638/ https://www.ncbi.nlm.nih.gov/pubmed/35690957 http://dx.doi.org/10.1007/s11030-022-10468-8

Ejemplares similares

Pharmacophore mapping approach to find anti-cancer phytochemicals with metformin-like activities against transforming growth factor (TGF)-beta receptor I kinase: An in silico study
por: Reza, Rumman, et al.
Publicado: (2023)

Modeling of MT. P495, an mRNA-based vaccine against the phosphate-binding protein PstS1 of Mycobacterium tuberculosis
por: Shahrear, Sazzad, et al.
Publicado: (2022)

SARS-CoV-2 Proteins Exploit Host’s Genetic and Epigenetic Mediators for the Annexation of Key Host Signaling Pathways
por: Khan, Md. Abdullah-Al-Kamran, et al.
Publicado: (2021)

A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine design
por: Sharmin, Refat, et al.
Publicado: (2014)

Functional Analysis of Hypothetical Proteins of Vibrio parahaemolyticus Reveals the Presence of Virulence Factors and Growth-Related Enzymes With Therapeutic Potential
por: Shahrear, Sazzad, et al.
Publicado: (2022)

Drug and Anti-Viral Peptide Design to Inhibit the Monkeypox Virus by Restricting A36R Protein
por: Miah, Mohammad Mohasin, et al.
Publicado: (2022)

Lung transcriptome of a COVID-19 patient and systems biology predictions suggest impaired surfactant production which may be druggable by surfactant therapy
por: Islam, Abul Bashar Mir Md. Khademul, et al.
Publicado: (2020)

SARS-CoV-2 mutations altering regulatory properties: Deciphering host's and virus's perspectives
por: Islam, Abul Bashar Mir Md. Khademul, et al.
Publicado: (2021)

Synthesis, in vitro bioassays, and computational study of heteroaryl nitazoxanide analogs
por: Ahmed, Tasmia, et al.
Publicado: (2021)

Functional Annotation of Hypothetical Proteins From the Enterobacter cloacae B13 Strain and Its Association With Pathogenicity
por: Dey, Supantha, et al.
Publicado: (2022)

Aberration of the modulatory functions of intronic microRNA hsa-miR-933 on its host gene ATF2 results in type II diabetes mellitus and neurodegenerative disease development
por: Islam, Abul Bashar Mir Md. Khademul, et al.
Publicado: (2020)

Perversely expressed long noncoding RNAs can alter host response and viral proliferation in SARS-CoV-2 infection
por: Turjya, Rafeed Rahman, et al.
Publicado: (2020)

Epigenetic Regulator miRNA Pattern Differences Among SARS-CoV, SARS-CoV-2, and SARS-CoV-2 World-Wide Isolates Delineated the Mystery Behind the Epic Pathogenicity and Distinct Clinical Characteristics of Pandemic COVID-19
por: Khan, Md. Abdullah-Al-Kamran, et al.
Publicado: (2020)

Repurposing strategies on pyridazinone-based series by pharmacophore- and structure-driven screening
por: Floresta, Giuseppe, et al.
Publicado: (2020)

Effect of non-synonymous SNP on JAK1 protein structure and subsequent function
por: Liza, Rozario, et al.
Publicado: (2019)

Genomic and evolutionary features of two AHPND positive Vibrio parahaemolyticus strains isolated from shrimp (Penaeus monodon) of south-west Bangladesh
por: Ahmmed, Shawon, et al.
Publicado: (2019)

Transcriptome of nasopharyngeal samples from COVID-19 patients and a comparative analysis with other SARS-CoV-2 infection models reveal disparate host responses against SARS-CoV-2
por: Islam, Abul Bashar Mir Md. Khademul, et al.
Publicado: (2021)

Heat-Induced Interaction of Milk Proteins: Impact on Yoghurt Structure
por: Asaduzzaman, Md, et al.
Publicado: (2021)

A review on structural, non-structural, and accessory proteins of SARS-CoV-2: Highlighting drug target sites
por: Jahirul Islam, Md., et al.
Publicado: (2023)

Mutational profiles of marker genes of cervical carcinoma in Bangladeshi patients
por: Sharmin, Shahana, et al.
Publicado: (2021)

Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening
por: Halim, Sobia A., et al.
Publicado: (2017)

Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein
por: Hossain, Mohammad Uzzal, et al.
Publicado: (2016)

Computational Repurposing of Mitoxantrone-Related Structures against Monkeypox Virus: A Molecular Docking and 3D Pharmacophore Study
por: Preet, Gagan, et al.
Publicado: (2022)

Elucidation of Protein Structural and Pharmacophore Features Based on Sequence Clustering by Common Neighbor Comparisons
por: Kho, Richard, et al.
Publicado: (2002)

Structural basis for DEAH-helicase activation by G-patch proteins
por: Studer, Michael K., et al.
Publicado: (2020)

Structure based pharmacophore modeling, virtual screening, molecular docking and ADMET approaches for identification of natural anti-cancer agents targeting XIAP protein
por: Opo, Firoz A. Dain Md, et al.
Publicado: (2021)

Non-B DNA Secondary Structures and Their Resolution by RecQ Helicases
por: Sharma, Sudha
Publicado: (2011)

Kinetic and structural mechanism for DNA unwinding by a non-hexameric helicase
por: Carney, Sean P., et al.
Publicado: (2021)

Significance of Monoclonal Antibodies against the Conserved Epitopes within Non-Structural Protein 3 Helicase of Hepatitis C Virus
por: Bian, Yixin, et al.
Publicado: (2013)

Development of antibacterial nanofibrous wound dressing and conceptual reaction mechanism to deactivate the viral protein by Nigella sativa extract
por: Shahid, Md Abdus, et al.
Publicado: (2021)

Structure and Non-Structure of Centrosomal Proteins
por: Dos Santos, Helena G., et al.
Publicado: (2013)

Pharmacophore Modelling-Based Drug Repurposing Approaches for SARS-CoV-2 Therapeutics
por: Rampogu, Shailima, et al.
Publicado: (2021)

Targeting non-structural proteins of Hepatitis C virus for predicting repurposed drugs using QSAR and machine learning approaches
por: Kamboj, Sakshi, et al.
Publicado: (2022)

Author Correction: Structure based pharmacophore modeling, virtual screening, molecular docking and ADMET approaches for identification of natural anti-cancer agents targeting XIAP protein
por: Opo, Firoz A. Dain Md, et al.
Publicado: (2021)

Common Pharmacophore of Structurally Distinct Small-Molecule Inhibitors of Intracellular Retrograde Trafficking of Ribosome Inactivating Proteins
por: Yu, Shichao, et al.
Publicado: (2013)

Artifact suppression and analysis of brain activities with electroencephalography signals
por: Rashed-Al-Mahfuz, Md., et al.
Publicado: (2013)

Exploring protein hotspots by optimized fragment pharmacophores
por: Bajusz, Dávid, et al.
Publicado: (2021)

Tautomerism in structure-based 3D pharmacophore modeling
por: Seidel, Thomas, et al.
Publicado: (2008)

Graph Eigen Decomposition-Based Feature-Selection Method for Epileptic Seizure Detection Using Electroencephalography †
por: Molla, Md. Khademul Islam, et al.
Publicado: (2020)

In Silico Structural and Functional Annotation of Hypothetical Proteins of Vibrio cholerae O139
por: Islam, Md. Saiful, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_o96m6jnah9i6kpr6d4pfrhnq3k