Uncovering the Mechanism of Drug Resistance Caused by the T790M Mutation in EGFR Kinase From Absolute Binding Free Energy Calculations

The emergence of drug resistance may increase the death rates in advanced non-small cell lung cancer (NSCLC) patients. The resistance of erlotinib, the effective first-line antitumor drug for NSCLC with the L858R mutation of epidermal growth factor receptor (EGFR), happens after the T790M mutation o...

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Detalles Bibliográficos
Autores principales: Zhou, Huaxin, Fu, Haohao, Liu, Han, Shao, Xueguang, Cai, Wensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189374/
https://www.ncbi.nlm.nih.gov/pubmed/35707225
http://dx.doi.org/10.3389/fmolb.2022.922839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189374/
https://www.ncbi.nlm.nih.gov/pubmed/35707225
http://dx.doi.org/10.3389/fmolb.2022.922839

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