TLR4 aggravates microglial pyroptosis by promoting DDX3X‐mediated NLRP3 inflammasome activation via JAK2/STAT1 pathway after spinal cord injury

BACKGROUND: Toll‐like receptor 4 (TLR4) participates in the initiation of neuroinflammation in various neurological diseases, including central nervous system injuries. NLR family pyrin domain containing 3 (NLRP3) inflammasome‐mediated microglial pyroptosis is crucial for the inflammatory response d...

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Detalles Bibliográficos
Autores principales: Wang, Jin, Zhang, Fan, Xu, Haocheng, Yang, Haiyuan, Shao, Minghao, Xu, Shun, Lyu, Feizhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189419/
https://www.ncbi.nlm.nih.gov/pubmed/35692100
http://dx.doi.org/10.1002/ctm2.894

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189419/
https://www.ncbi.nlm.nih.gov/pubmed/35692100
http://dx.doi.org/10.1002/ctm2.894

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