Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection

BACKGROUND: Cell-based therapies for multiple sclerosis (MS), including those employing autologous bone marrow-derived mesenchymal stromal cells (MSC) are being examined in clinical trials. However, recent studies have identified abnormalities in the MS bone marrow microenvironment. OBJECTIVE: We ai...

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Detalles Bibliográficos
Autores principales: Sarkar, Pamela, Redondo, Juliana, Hares, Kelly, Bailey, Steven, Georgievskaya, Anastasia, Heesom, Kate, Kemp, Kevin C, Scolding, Neil J, Rice, Claire M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Original Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189727/
https://www.ncbi.nlm.nih.gov/pubmed/34841955
http://dx.doi.org/10.1177/13524585211060686

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189727/
https://www.ncbi.nlm.nih.gov/pubmed/34841955
http://dx.doi.org/10.1177/13524585211060686

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