Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules

[Image: see text] Major advances have recently defined functions for human mono-ADP-ribosylating PARP enzymes (mono-ARTs), also opening up potential applications for targeting them to treat diseases. Structural biology combined with medicinal chemistry has allowed the design of potent small molecule...

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Detalles Bibliográficos
Autores principales: Nizi, Maria Giulia, Maksimainen, Mirko M., Lehtiö, Lari, Tabarrini, Oriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189837/
https://www.ncbi.nlm.nih.gov/pubmed/35608571
http://dx.doi.org/10.1021/acs.jmedchem.2c00281

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189837/
https://www.ncbi.nlm.nih.gov/pubmed/35608571
http://dx.doi.org/10.1021/acs.jmedchem.2c00281

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