Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer

[Image: see text] A recently proposed strategy to overcome multidrug resistance (MDR) in cancer is to target the collateral sensitivity of otherwise resistant cells. We designed a library of 120 compounds to explore the chemical space around previously identified 8-hydroxyquinoline-derived Mannich b...

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Detalles Bibliográficos
Autores principales: Pape, Veronika F. S., Palkó, Roberta, Tóth, Szilárd, Szabó, Miklós J., Sessler, Judit, Dormán, György, Enyedy, Éva A., Soós, Tibor, Szatmári, István, Szakács, Gergely
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189845/
https://www.ncbi.nlm.nih.gov/pubmed/35613553
http://dx.doi.org/10.1021/acs.jmedchem.2c00076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189845/
https://www.ncbi.nlm.nih.gov/pubmed/35613553
http://dx.doi.org/10.1021/acs.jmedchem.2c00076

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