Abrogation of Notch Signaling in Embryonic TECs Impacts Postnatal mTEC Homeostasis and Thymic Involution

Notch signaling is crucial for fate specification and maturation of thymus-seeding progenitors along the T-cell lineage. Recent studies have extended the role of Notch signaling to thymic epithelial cells (TECs), showing that Notch regulates TEC progenitor maintenance and emergence of medullary TECs...

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Detalles Bibliográficos
Autores principales: García-León, María Jesús, Mosquera, Marta, Cela, Carmela, Alcain, Juan, Zuklys, Saulius, Holländer, Georg, Toribio, María L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189879/
https://www.ncbi.nlm.nih.gov/pubmed/35707539
http://dx.doi.org/10.3389/fimmu.2022.867302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189879/
https://www.ncbi.nlm.nih.gov/pubmed/35707539
http://dx.doi.org/10.3389/fimmu.2022.867302

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