Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666

Branched actin networks polymerized by the Actin-related protein 2 and 3 (Arp2/3) complex play key roles in force generation and membrane remodeling. These networks are particularly important for cell migration, where they drive membrane protrusions of lamellipodia. Several Arp2/3 inhibitory compoun...

Descripción completa

Detalles Bibliográficos
Autores principales: Fokin, Artem I., Chuprov-Netochin, Roman N., Malyshev, Alexander S., Romero, Stéphane, Semenova, Marina N., Konyushkin, Leonid D., Leonov, Sergey V., Semenov, Victor V., Gautreau, Alexis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189929/
https://www.ncbi.nlm.nih.gov/pubmed/35707404
http://dx.doi.org/10.3389/fphar.2022.896994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189929/
https://www.ncbi.nlm.nih.gov/pubmed/35707404
http://dx.doi.org/10.3389/fphar.2022.896994

Ejemplares similares