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Synthesis, Screening and Characterization of Novel Potent Arp2/3 Inhibitory Compounds Analogous to CK-666

Branched actin networks polymerized by the Actin-related protein 2 and 3 (Arp2/3) complex play key roles in force generation and membrane remodeling. These networks are particularly important for cell migration, where they drive membrane protrusions of lamellipodia. Several Arp2/3 inhibitory compoun...

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Detalles Bibliográficos
Autores principales:	Fokin, Artem I., Chuprov-Netochin, Roman N., Malyshev, Alexander S., Romero, Stéphane, Semenova, Marina N., Konyushkin, Leonid D., Leonov, Sergey V., Semenov, Victor V., Gautreau, Alexis M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189929/ https://www.ncbi.nlm.nih.gov/pubmed/35707404 http://dx.doi.org/10.3389/fphar.2022.896994

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