Discovery of a High Affinity Adenosine A(1)/A(3) Receptor Antagonist with a Novel 7-Amino-pyrazolo[3,4-d]pyridazine Scaffold

[Image: see text] Here we describe the design and synthesis of pyrazolo[3,4-d]pyridazines as adenosine receptor (AR) ligands. We demonstrate that the introduction of a 3-phenyl group, together with a 7-benzylamino and 1-methyl group at the pyrazolopyridazine scaffold, generated the antagonist compou...

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Detalles Bibliográficos
Autores principales: Suchankova, Anna, Stampelou, Margarita, Koutsouki, Klontiana, Pousias, Athanasios, Dhingra, Lakshiv, Barkan, Kerry, Pouli, Nicole, Marakos, Panagiotis, Tenta, Roxane, Kolocouris, Antonios, Lougiakis, Nikolaos, Ladds, Graham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190043/
https://www.ncbi.nlm.nih.gov/pubmed/35707146
http://dx.doi.org/10.1021/acsmedchemlett.2c00052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190043/
https://www.ncbi.nlm.nih.gov/pubmed/35707146
http://dx.doi.org/10.1021/acsmedchemlett.2c00052

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