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Impaired Interleukin‐18 Signaling in Natural Killer Cells From Patients With Systemic Juvenile Idiopathic Arthritis

OBJECTIVE: Systemic juvenile idiopathic arthritis (sJIA) is characterized by fever, arthritis, rash, hepatosplenomegaly, and macrophage activation syndrome; however, its pathogenesis is still unclear. Elevated serum interleukin (IL)‐18 concentrations and decreased natural killer (NK) cell activity a...

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Detalles Bibliográficos
Autores principales: Ohya, Takashi, Nishimura, Kenichi, Murase, Ayako, Hattori, Seira, Ohara, Asami, Nozawa, Tomo, Hara, Ryoki, Ito, Shuichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9190221/
https://www.ncbi.nlm.nih.gov/pubmed/35275436
http://dx.doi.org/10.1002/acr2.11426